Services
Reproductive Genetics Program

InsighT-Adv and InsighT

The world's most advanced and proven NIPS tests now brought to you in India by Lilac Insights.

InsighT-Adv & InsighT are the most advanced NIPS (also known as cff-DNA screening) tests exclusively available from Lilac Insights in India. These tests are used to identify common chromosomal disorders in the growing baby (fetus) with an accuracy/detection rate of >99% for Trisomy 21 (Down Syndrome), Trisomy 18 (Edward's Syndrome) and Trisomy 13 (Patau Syndrome), Sex Chromosome Aneuploidies (SCAs) and Selected Microdeletion disorders.

Baby's (fetus) DNA from placenta circulates in the mother's blood during pregnancy. This DNA has their genetic information. InsighT-Adv/ InsighT tests use the mother's blood sample to determine the risk if the developing baby has the above mentioned chromosomal conditions that can affect their health and development.

InsighT-Adv/ InsighT can be done after 10 weeks of pregnancy (gestation age >=10 weeks) to ensure the accuracy and reliability of the test. Globally >10 million pregnant women opt for Non-Invasive Prenatal Screening (NIPT/NIPS) tests to take confident decisions about their pregnancy outcome.



Clinical Information - NIPT Test

InsighT-Adv & InsighT tests are based on the world's most advanced, proprietary & patented NIPS technology (TACS technology) which is preferred by millions of pregnant women and thousands of clinicians worldwide as it offers unmatched precision and accuracy. This technology is developed by NIPD Genetics (Cyprus) and is brought to you in India by Lilac Insights.

TACS (Target Capture Enrichment) technology is an innovative patented technology which overcomes the limitations of other available NIPS tests in India which use older technologies. Both these tests have been clinical validated for the conditions reported by them and thereby deliver unmatched clinical performance. Therefore, these are preferred by the country's leading medical experts for their patients to ensure reliable insights in critical situations.

We have tailored our tests to best fit your pregnancy needs.

InsighT Adv InsighT Adv
Genetic condition Screened Singleton pregnancy Twin/ Vanished twin pregnancy Singleton pregnancy Twin/ Vanished twin pregnancy
Common Aneuploidies Down syndrome (T21)
Edwards’ syndrome (T18)
Patau syndrome (T13)
SCAs 5 types of sex chromosomes aneuploidies* (SCAs)
Microdeletions DiGeorge syndrome
Smith-Magenis syndrome
Wolf-Hirschhorn syndrome
1p36 deletion syndrome

*Sex chromosome aneuploidies cannot be screened in twin and vanished twin pregnancies.
# Only Twin & vanishing-twin pregnancies with donor egg are not eligible for InsighT-Adv & InsighT tests.

Note: Sex of the fetus is not determined/ reported by Lilac Insights as per PC-PNDT Act, 2003

Here are 10 reasons why you can blindly trust on InsighT-Adv & InsighT vs other NIPS/NIPT tests!

Still have queries about NIPS/NIPT testing. Go through our FAQ section to get more clarity.

FAQs

These are advanced prenatal screening tests exclusively offered by Lilac Insights using advanced and patented TACS technology. The test is conducted on pregnant woman’s blood sample whose pregnancy maybe at a high risk of carrying a fetus with most common genetic abnormalities. These tests are screening tests for common chromosomal disorders with an accuracy/detection rate (>99%) for Trisomy 21, Trisomy 18 and Trisomy 13, Sex Chromosome Aneuploidies (SCAs) and selected Microdeletion disorders.

Non Invasive Prenatal Screening Tests give expecting parents Peace of Mind by providing early and accurate information about the health of their unborn baby with respect to chromosomal abnormalities in advance.

  • InsighT Adv/ InsighT can be performed as early as 10 weeks.
  • InsighT Adv/ InsighT involves zero risk of miscarriage as the test is performed on peripheral blood sample of the pregnant woman.
  • InsighT Adv/ InsighT tests are highly accurate screening tests with a reported detection rate of >99.9% for Down Syndrome, Edwards Syndrome, Patau Syndrome.
  • They also offer reliable screening for Sex chromosome (X & Y chromosome related) abnormalities and certain microdeletion disorders.
  • Opting for InsighT-Adv/ InsighT (NIPS/NIPT) from Lilac Insights, will help you to take confident decisions about your further pregnancy management.
  • Other advantages are mentioned on the page above - Click here to view more

In principle, all these tests analyze the cell-free fetal DNA (cff-DNA) present in mother’s blood.

In terms of technology, InsighT-Adv and InsighT both the tests utilize the latest patented TACS technology (developed by our technology partner, NIPD Genetics). These tests differ in the genetic conditions/ abnormalities which they can cover.

  • InsighT-Adv covers (screens) 12 genetic conditions (8 common genetic conditions + 4 microdeletion syndromes) whereas,
  • InsighT covers (screens) 8 common genetic conditions.

While both these are performed on maternal/ mother’s blood sample.

  • InsighT range of tests analyses the DNA of the fetus that is circulating in the mother’s blood whereas biochemical marker test (Dual/Triple/Quadruple marker) analyses the levels of certain pregnancy associated hormones in the mother’s blood during the certain period of pregnancy.
  • Another difference between these two types of tests is the detection rate: InsighT-Adv/ InsighT offers >99.9% detection rate for common chromosomal abnormalities whereas the detection rate for biochemical marker screening ranges between 65 to 90%, for common chromosomal abnormalities, depending on the chosen screening test protocol.
  • InsighT range of NIPS screening test can screen for more chromosomal abnormalities than the conditions screened by biochemical screening options.
  • InsighT range of tests can provide a more confident reassurance where NIPS results show low risk for tested genetic disorders. It also aids in more confident decision making of invasive diagnostic testing much needed in cases where NIPS results show high risk of the fetus being affected by certain genetic disorder.

As these are screening tests, in case of high-risk results, you will need to undergo invasive procedures such as amniocentesis/CVS followed by diagnostic tests to confirm the final diagnosis. InsighT-Adv & InsighT are the only tests in India that guarantee the reimbursement for further confirmatory testing for all patients who receive high-risk results after undergoing these tests.

The reimbursement will be provided for the charges of invasive procedure* as well as the diagnostic testing# (Diagnostic test to be done at Lilac Insights only) if the patient opts for it after receiving the results. This helps to reduce the additional expenses for further confirmatory testing.

*upto Rs. 8000 for singleton pregnancies & upto Rs. 15000 for twin pregnancies

#Karyotyping + FISH analysis for diagnosis of Aneuploidies; ALTUM (chromosomal microarray) for diagnosis of microdeletions

These tests can be performed as early as 10 weeks of pregnancy.

You can opt for a pre-test counselling with our prenatal genetic counsellor to understand the need and importance of the test.

Both these tests can be performed in IVF pregnancies and twin pregnancies. Only IVF twin or vanished twin pregnancies with donor egg are not eligible for these tests.

These tests require 10 ml of peripheral blood of pregnant woman in a specialized tube (Streck tube) post 10 weeks of pregnancy. Sample can be drawn by any trained phlebotomist in preferred clinic*

*PC-PNDT registered clinic/ center/ hospital.

There is no risk associated with NIPS testing for fetus or mother, as the test is performed on mother’s regular blood sample.

*A minor redness or swelling can appear at the spot of blood collection in rare case which can be managed easily.

These tests reveal a risk assessment as either High risk or Low risk for a particular or more than one genetic condition that they cover.

Low-risk: Your baby is very unlikely to have Down syndrome, Edwards' syndrome, Patau syndrome, Sex chromosome aneuploidies, Selected micro-deletion disorders.

High-risk: Your baby is very likely to be affected with the condition being highlighted as high risk by the test and hence confirmatory/ diagnostic testing is recommended.

No call: This happens in rare situations <0.5% of cases. Even after processing the second blood sample post-redraw, if the fetal fraction is found to be lower than the standard FF% cut-off (<4%), you will receive the no-call report. A refund of the test charges paid by you will be processed (minimal sample processing and transportation charges will be deducted).

If the Fetal Fraction (FF%) in your blood sample (seen in <1-2% cases) is found to be below the standard FF% cut-off (<4%), you will be asked to provide the repeat blood sample. Such sample will be processed at no extra cost.

Fetal Fraction (FF%) is the amount of fetal DNA released & circulating into mother's blood stream which varies for each pregnant mother. Results reported in less than 4% fetal fraction will not be helpful for you and your clinician to take any decision for your pregnancy. Only adequate quantity of fetal DNA in your blood can ensure the accuracy and reliability of the results and help in critical decision making.

Fetal fraction % increases as your pregnancy progresses further. Performing the test again after some time period on new blood sample has given results in >99% cases.

If an InsighT-Adv/ InsighT test report a high risk for a particular condition, the second step is to go for diagnostic testing i.e. Confirmatory Tests after consultation with your doctor & prenatal genetic counsellor.

Confirmatory prenatal diagnosis involves analysis of amniocytes or chorionic villi to confirm whether the fetus is affected with the chromosomal abnormality or not.

InsighT-Adv & InsighT are the only tests in India that guarantee the reimbursement for further confirmatory testing for all patients who receive high-risk results after undergoing these tests.

The reimbursement will be provided for the charges of invasive procedure* as well as the diagnostic testing# (Diagnostic test to be done at Lilac Insights only) if the patient opts for it after receiving the results. This helps to reduce the additional expenses for further confirmatory testing.

Note: No clinical decisions should be taken solely based on any screening results unless the diagnosis has been ascertained.

*upto Rs. 8000 for singleton pregnancies & upto Rs. 15000 for twin pregnancies

#Karyotyping + FISH analysis for diagnosis of Aneuploidies; ALTUM (chromosomal microarray) for diagnosis of microdeletions

Low risk results imply that the probability of your pregnancy being affected with the screened genetic abnormalities is very low. For more information: You can opt for a pre-test/ post-test counselling with our prenatal genetic counsellor or consult your doctor.

Confirmatory tests which check for chromosomal abnormalities require samples of fetus obtained through invasive procedures. Though these invasive procedures are performed by experts, still there is a risk of miscarriage due to the innate nature of the procedure. With higher accuracy, InsighT-Adv / InsighT test helps identify those pregnancies which are at a high risk of having a chromosomal abnormality & hence warrant an invasive test. The reimbursement policy for InsighT-Adv/InsighT high risk result cases covers you from the further cost burden of invasive testing.

The pregnancies that are reported as low risk by InsighT-Adv/ InsighT tests need not be exposed to undue harm by doing an invasive procedure can continue with the regular follow-up visits and USG scan monitoring.

InsighT-Adv/ InsighT tests are usually recommended to pregnant women by gynecologist/obstetrician or fetal medicine consultants, considering their risk factor for the pregnancy being affected with chromosomal abnormalities.

  • A screening test with highest sensitivity & specificity for common genetic disorders
  • Advanced maternal age (35 years and above)
  • Reassurance after receiving high/Intermediate risk results from biochemical screening tests
  • History of prior pregnancy with chromosomal abnormalities
  • Fetal ultra sonographic findings suggestive of Trisomy 21, Trisomy 18 and Trisomy 13
  • Pregnancy through IVF (In-vitro fertilization)
  • Ideally, InsighT-Adv/ InsighT can be offered for all pregnancies based on the eligibility criteria to know the health of their fetus.

Ideally you should be screened for the most common & widespread clinically relevant genetic disorders which have been included in these tests to reduce your unwanted anxiety.

In addition, if there is any family/previous pregnancy history of any specific genetic disorder then you will require additional tests specific to those disorders which your consulting doctor will decide.

In most cases, your referring doctor will ask you to do these tests from Lilac Insight. But in case your doctor who isn’t familiar with Lilac Insights, you can Contact Us & we will facilitate the process.

Normally one screening test is all that is required. In few cases, especially for patients with high risk/ intermediate risk results from biochemical screening, your doctor may suggest you to undergo NIPS as a follow-up reassuring test before opting an invasive confirmatory Test.

A trained phlebotomist or a nursing staff member can draw the sample for the test.

InsighT-Adv/ InsighT test are not routine pathology tests. They are specialized genetic tests which need special attention, latest machines and skilled personnel to process the samples and work on then.

In routine test such as hemoglobin test, fixed ranges or cutoffs are used to provide reports while InsighT-Adv/ InsighT (NIPS) screening test requires in depth advanced genetic analysis for each case.

Lilac Insights being advanced dedicated genetic diagnostic center is well equipped with technologies and experts to conduct & provides accurate reports to clinicians and patients.

InsighT/ InsighT-Adv/ InsighT Plus tests are exclusively offered by Lilac Insights. As these NIPS testing requires specialized technology and expertise, they should be performed at specialized laboratories such as Lilac Insights to ensure the confident and reliable reports. Such laboratory should be registered under the PCPNDT act of India.

In most cases, the referring doctor decides where to send these NIPS/NIPT samples. You can also ask your doctor to recommend InsighT Adv/ InsighT test at Lilac Insights.

Being market leaders, there is a high chance that your doctor may be already using Lilac Insights’ genetic testing services. You may discuss this with your doctor & upon mutual agreement, provide us with the contact details. We will get in touch with the concerned person & facilitate the process.

Your doctor should be able to address all your questions. You may feel free to get in touch with our Genetic counselors if you wish to understand more about the test and its results.

Click here for e-Genetic Consultation & Counseling.

NIPT test results normally takes about 10-12 working days post arrival of blood sample at the lab. Your doctor should have a digital report by the end of the second week.

If the Fetal Fraction (FF%) in your blood sample (seen in <1-2% cases) is found to be below the standard FF% cut-off (<4%), you will be asked to provide the repeat blood sample which will be processed at no extra cost.

Fetal Fraction (FF%) is the amount of fetal DNA released & circulating into mother's blood stream. Only adequate quantity of fetal DNA can ensure the accuracy and reliability of the results.

These advanced genetic NIPS tests are available pan-India at reasonable and affordable cost. For pricing related queries you can contact your doctor or Local Lilac Insights representative or you can also call us at +91 22 4184 1438.

You can simply talk to your consulting Obstetrician or Gynecologist or Fetal medicine expert. As Lilac Insights is a market leader, there is high chance that your doctor is already availing any of our services. If your doctor is not familiar with Lilac Insights, you may provide us with your doctor’s details & we will get in touch with them to facilitate your NIPS testing.

You may also Contact Us & we will guide you through the process.

Enquiry for Non Invasive Prenatal Test (NIPT/NIPS)
reload