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{SampleId}

Dear {patientName},

We are glad to see that you have opted this test with us. Your genetic Counselling report captures the major highlights from your pregnancy InsightomeTM genetic test report & incorporates the observations of your accredited genetic counsellor. We sincerely hope you will find this report to be a helpful resource to guide you in managing your pregnancy associated health, nutritional and lifestyle aspects in alignment with your genetic profile. It will assist you in health optimization by synchronizing your nature (genes) and nurture (lifestyle) & contribute in obtaining improved pregnancy outcomes.

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Pedigreee

Shows the presence of a trait within your family across one or more generations

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{motherAge}
{pateintName}
{pateintAge}
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Discussion

{patientName} opted for the InsightomeTM genetic counselling session in order to review and understand the findings of her personalized genome report.

Specific Concerns

{pateintName} intends to gain further insights about her gestational diabetes and weight gain issues.

Why genetic counselling is a part of pregnancy Insightome program?

Our genetic counselling is driven by the primary objective of helping you understand and interpret the InsightomeTM genetic test report results for its effective alignment and synergism with your pregnancy. The counsellors evaluate the interaction between your genes and your real life personal and family health parameters to provide meaningful interventions. The illustration below captures how the interplay between your genetic profile and your environment contribute to manifestation of medical conditions.

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For many pregnancies associated medical conditions (like gestational diabetes or preeclampsia) each woman has some predisposition (risk) of developing the condition during their pregnancy. This diagram represents this as a bucket- a woman experiences the condition when their bucket gets full up. Most health conditions arise due to a combination of genetic and other risk factors.

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Everyone starts life with some genetic predisposition (risk) factors for the condition. Some women have very few, some women have a lot. You are born with this risk and you can’t change it. Insightome aims to measure this predisposition for you.

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Over the course of life, we are exposed to other factors that increases the chance of them experiencing the condition.

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If you had more genetic risk factors in your bucket to begin with, it takes fewer other risk factors to fill the bucket and result in the health condition.

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If you had more genetic risk factors in your bucket to begin with, it takes fewer other risk factors to fill the bucket and result in the health condition.

Even if you have a ‘high genetic risk’ of a particular condition, for most health conditions, having a high genetic risk does not mean you’ll get it.

By working on the factors you can change, you might be able to reduce the change of developing a health condition, even if you have a high genetic risk.

Your certified Insightome counsellors takes into consideration these aspects to provide interventions that can help to reduce the chances of developing medical conditions or nutritional deficiencies during your pregnancy. These recommendations help you and your treating clinician plan your pregnancy better to improve the pregnancy outcomes.

Pregnancy Insightome Genetic Tests: Trait symptoms & Management

Your Insightome test has reflected the following traits with elevated and moderate predispositions. We have listed the symptoms, that you should be mindful of, pertaining to these traits. We recommend that you should reach out to your treating clinician in case you experience any of these symptoms for appropriate and timely management.

Traits Sings and Symptoms one should look out for (A) When to see doctor (B) References
Gestational Diabetes
  1. Feeling thirsty
  2. Fatigue feeling tired constantly.
  3. Weight loss even with increased appetite.
  4. Increased frequent urination.
  5. Yeast infections.
  6. Blurred vision.
 All pregnant women are screened for gestational diabetes, whether they show any symptoms or not as for many pregnant women, gestational diabetes does not cause any recognizable symptoms. https://www.webmd.com/baby/symptoms-of-gestational-diabetes (A)

https://www.everydayhealth.com/gestational-diabetes/guide/ (B)
Gestational Weight Gain Most pregnant women:

  1. Gain Between 10kg and 12.5kg.
  2. Put on most of the weight after week 20.
 Putting on too much or too little weight can lead to health problems for you or your unborn baby. Consult your doctor if you weigh.

  1. More than 100 kg.
  2. Less than 50 kg.
 https://www.nhs.uk/pregnancy/related-conditions/common-symptoms/weight-gain/ (A)

https://www.nhs.uk/pregnancy/related-conditions/common-symptoms/weight-gain/ (B)
Traits Symptoms ones should look out for (A) When to see doctor (B) References
Folate Levels
  1. Fatigue.
  2. Feeling short of breath.
  3. Pale skin.
  4. Racing heart.
  5. Feeling hungry.
  6. Grey hair.
  7. Mouth sores.
  8. Tongue swelling.
 As soon as the symptoms are noticed. If left untreated, some of these could get worse and lead to anaemia. https://www.healthline.com/health/folate-deficiency#folic-acid-deficiency-in-pregnancy (A)

https://www.webmd.com/a-to-z-guides/folic-acid-deficiency-anemia (B)
Iron Deficiency Iron-deficiency anaemia- occurs when the body doesn't have enough iron to produce adequate amounts of haemoglobin. Symptoms-

  1. Pale skin, lips, and nails.
  2. Feeling tired.
  3. Dizziness.
  4. Shortness of breath.
  5. Rapid heartbeat.
  6. Trouble concentrating.
 Putting on too much or too little weight can lead to health problems for you or your unborn baby. Consult your doctor if you weigh.

  1. More than 100 kg.
  2. Less than 50 kg.
 https://www.nhs.uk/pregnancy/related-conditions/common-symptoms/weight-gain/ (A)

https://www.nhs.uk/pregnancy/related-conditions/common-symptoms/weight-gain/ (B)
Traits Symptoms ones should look out for (A) When to see doctor (B) References
Iron Overload
  1. Constipation.
  2. Abdominal cramping.
  3. Increased risk for gestational diabetes.
  4. Pres-eclampsia.
  5. Joint pain.
  6. Fatigue/Weakness.
 Mostly Iron overload doesn’t show specific signs and symptoms, other than elevated levels of iron in blood. Two key tests to detect:

  1. Ferritin concentration.
  2. Serum Tranferrin.
 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7173188/ (A)

https://www.mayoclinic.org/diseases-conditions/hemochromatosis/diagnosis-treatment/drc-20351448 (B)
Vitamin D Levels
  1. Frequent illness.
  2. Fatigue and tiredness.
  3. Lower back pain.
  4. Depression.
  5. Impaired wound healing (slow wound healing).
  6. Low bone mineral density.
  7. Hair loss
  8. Muscle pain
  9. Weight gain
  10. Anxiety
 If you notice any possible symptoms and especially if you have any risk factors. https://www.healthline.com/nutrition/vitamin-d-deficiency-symptoms#causes (A)

https://www.healthline.com/nutrition/vitamin-d-deficiency-symptoms#causes (B)
Traits Symptoms ones should look out for (A) When to see doctor (B) References
Vitamin C Levels
  1. Rough and bumpy skin
  2. Cork-screw shaped hair
  3. Bright red hair follicles
  4. Spoon-shaped fingernails with red spot or lines
  5. Dry damaged skin with easy bruising
  6. Slowly healing wounds
  7. Painful and swollen joints
  8. Weak bones
  9. Bleeding gums and tooth loss
  10. Poor immunity
  11. Persistent iron deficiency
  12. Anaemia
  13. Fatigue and poor mood
  14. Chronic inflammation and oxidative stress
 If you notice any possible symptoms and especially if you have any risk factors. Your doctor may suspect vitamin C deficiency after asking you careful questions about your diet and listening to the symptoms that you have. A blood test can be taken to measure vitamin C levels and may help to confirm the diagnosis.

Your doctor may also suggest some other blood tests to check for other deficiencies in your diet. For example, vitamin C is also needed for the absorption of iron from food.

Therefore, iron deficiency often occurs in people who are deficient in vitamin C. 		https://www.healthline.com/nutrition/vitamin-c-deficiency-symptoms#TOC_TITLE_HDR_17 (A)

https://patient.info/healthy-living/vitamin-c-deficiency-leaflet (B)
Traits Symptoms ones should look out for (A) When to see doctor (B) References
Vitamin B12 Levels
  1. Weakness, tiredness, or light-headedness
  2. Heart palpitations and shortness of breath
  3. Pale skin
  4. Smooth tongue
  5. Constipation, diarrhoea, loss of appetite, or gas
  6. Nerve problems like numbness or tingling, muscle weakness, and problems walking
  7. Vision loss
  8. Mental problems like depression, memory loss, or behavioural changes
 If you have any of the symptoms mentioned, you should contact your doctor immediately. It is very important you share all your concerns with your doctor to prevent any vitamin deficiencies from causing damage to your body or your developing baby’s body. https://www.webmd.com/diet/vitamin-b12-deficiency-symptoms-causes (A)

https://americanpregnancy.org/healthy-pregnancy/pregnancy-health-wellness/vitamin-b-pregnancy/ (B)
Vitamin B6 Levels
  1. Skin rashes
  2. Cracked and sore lips
  3. Sore and glossy tongue
  4. Mood changes
  5. Weakened immune function
  6. Tiredness and low energy
  7. Tingling and pain in hand and feet
  8. Seizures
 Consult your doctor if you experience any of the symptoms mentioned. Be sure you know the Vitamin B6 amount supplied in your prenatal vitamin and the amount in your diet does not exceed 100 mg per day. https://www.healthline.com/nutrition/vitamin-b6-deficiency-symptoms#TOC_TITLE_HDR_10 (A)

https://americanpregnancy.org/healthy-pregnancy/pregnancy-health-wellness/vitamin-b-pregnancy/ (B)
Traits Symptoms ones should look out for (A) When to see doctor (B) References
Calcium Levels
  1. Confusion or memory loss
  2. Muscle spasms
  3. Numbness and tingling om the hamds, feet and face
  4. Depression
  5. Hallucinations
  6. Muscle cramps
  7. Weak and brittle nails
  8. Easy fracturing of the bones
 As soon as the symptoms are noticed. If left untreated, some of these could get worse and lead to anaemia. https://www.healthline.com/health/calcium-deficiency-disease (A)

https://www.healthline.com/health/calcium-deficiency-disease (B)
Choline Levels
  1. Hypotension
  2. Sweating
  3. Vomiting
  4. Excessive salivation
  5. Liver toxicity
  6. Fishy body odour
 As soon as the symptoms are noticed. If left untreated, some of these could get worse and lead to anaemia. https://www.medicalnewstoday.com/articles/327117#deficiency (A)

https://www.medicalnewstoday.com/articles/327117#testing (B)
Vitamin B9 levels
  1. Paleness
  2. Shortness of breath (dyspnoea)
  3. Irritability
  4. Dizziness
  5. Tender and red tongue
  6. Mouth sores or mouth ulcers
  7. Reduced sense of taste
  8. Memory loss
  9. Difficulty concentrating, confusion and problems with judgement
 As soon as the symptoms are noticed. If left untreated, some of these could get worse and lead to anaemia. https://my.clevelandclinic.org/health/diseases/22198-folate-deficiency (A)

https://my.clevelandclinic.org/health/diseases/22198-folate-deficiency (B)
Traits Symptoms ones should look out for (A) When to see doctor (B) References
  1. Lack of energy
  2. Muscle weakness
  3. Depression
  4. Weight loss
  5. Diarrhoea
Vitamin A Levels
  1. Dry skin
  2. Dry eyes
  3. Night blindness
  4. Infertility and trouble conceiving
  5. Delayed growth
  6. Throat and chest infections
  7. Poor wound healing
  8. Acne and breakouts
 If you suspect that you have vitamin deficiency anaemia, you're likely to start by seeing your family doctor or a general practitioner. https://www.healthline.com/nutrition/vitamin-a-deficiency-symptoms#TOC_TITLE_HDR_9 (A)

https://www.mayoclinic.org/diseases-conditions/vitamin-deficiency-anemia/diagnosis-treatment/drc-20355031 (B)
Pre term birth
  1. Gestational diabetes
  2. High blood pressure
  3. Obesity
  4. Being underweight
  5. Smoking
  6. Alchohol consumption
  7. Blood clotting disorder
  8. Preeclampsia
  9. Twin pregnancy or IVF pregnancy
  10. Age-related factors
 Contact doctor on seeing symptoms.

  1. Backache, which usually will be at the lower back.
  2. Contractions every 10 minutes, breaking of water, loss of mucus plug
  3. Cramping in the lower abdomen
  4. Flu-like symptoms
  5. Nausea/Vomiting
  6. INcreased vaginal discharge
 https://www.who.int/news-room/fact-sheets/detail/preterm-birth (A)

https://www.who.int/news-room/fact-sheets/detail/preterm-birth (B)
Traits Symptoms ones should look out for (A) When to see doctor (B) References
  1. Vaginal bleeding
  2. Increased pressure on pelvis
Alloimmunization
  1. Haemolytic disease of the foetus and new-born
  2. Fetal haemorrhage
  3. Fetal loss
 In cases of severe anaemia during early pregnancy, generally before 24 weeks, IV immunoglobulin or steroids may be administered. Later in pregnancy, an intrauterine blood transfusion may be performed. A blood transfusion may also be required after birth. https://www.sciencedirect.com/science/article/pii/B9780323675093000093 (A)

https://www.osmosis.org/answers/alloimmunization#:~:text=Alloimmunization%20in%20blood%20transfusions%20may,breath%2C%20and%20increased%20heart%20rate. (B)
Hypothyroidism
  1. Fatigue
  2. Unable to stand cold temperatures
  3. Swelling of the face
  4. Weight gain
  5. Constipation
  6. Skin and hair changes, including dry skin and loss of eyebrows
  7. Carpal tunnel syndrome (hand tingling or pain)
  8. Slow heart rate
  9. Muscle cramps
  10. Trouble concentrating
  11. Irregular menstrual periods
 Contact the doctor as soon as your pregnant. The doctor will check the thyroid hormone levels every 4 to 6 weeks for the first half of pregnancy, and at least once after 30 weeks. https://www.stanfordchildrens.org/en/topic/default?id=hypothyroidism-and-pregnancy-85-P00426 (A)

https://www.niddk.nih.gov/health-information/endocrine-diseases/pregnancy-thyroid-disease#:~:text=Contact%20your%20doctor%20as%20soon,least%20once%20after%2030%20weeks. (B)

Results Overview

This section enumerates your pregnancy associated genetic predispositions and real life medical. lifestyle and nutritional conditions. Insightome certified genetic counsellors would help you interpret the correlation between the two for arriving at appropriate pregnancy focused interventions.

{patientName}'s Genetic Profile (Elevated & Moderate Predispositions)
Pregnancy Associated
Fetal Associated
Inflammation Associated
Endrocine Associated
Nutritional Associated
Real Life Status (Medical, Lifestyle & Nutritional Profile)
Medical Conditions
{patientName} Father Mother Brother
Lifestyle Conditions (self)
Nutritional Conditions (self)

Your Test Summary

Insightome Genetic Counselling Recommendations:

Evaluation:

  1. Conclusive statements from the Genetic counsellor that includes her Furtviews in the backdrop of the real life conditions.

Suggestion:

  1. her interventions suggested/ lifestyle or
  2. Other diagnostic tests (in consultation with the Medical Genetist)